JAN-FEB 2019

MedEsthetics—business education for medical practitioners—provides the latest noninvasive cosmetic procedures, treatment trends, product and equipment reviews, legal issues and medical aesthetics industry news.

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Page 15 of 68 | JANUARY/FEBRUARY 2019 13 Collagen-Based Scaffold for Revolumization Dermal fi llers have moved from collagen-based to hyaluronic acid and now a new product is bringing collagen back in the form of a scaffold designed to stimulate fi broblast proliferation. In the October is- sue of Aesthetic Surgery, Christopher Inglefi eld, BSc, MBBS, FRCS and colleagues published the results of their prospective, multicenter, open-label study of RPC (Rapidly Polymerizing Collagen) Pure-Collagen from EternoGen Aesthetics. RPC Pure-Collagen is a sterile, nonpyrogenic, viscous, clear solution com- posed of pure porcine collagen, ethylenediaminetet- raacetic acid (EDTA) and Mannitol that can be injected through a 30-gauge needle as a liquid. The liquid fi bril- izes in situ forming a natural, open 3D collagen matrix for bio-dermal restoration. The researchers treated 30 patients in the nasolabial fold and followed their outcomes for up 12 weeks after injection. A subset of patients was followed for up to nine months. The only adverse events were transient injection site reactions, which were mild or moderate in severity except for one case of severe bruising. There were no reports of hypersensitivity. The subjects all showed signifi cant improvement from baseline based on both Merz Aesthetic Scale and Global Aesthetic Improvement Scale assessments. COOLSCULPTING FOR SUBMANDIBULAR AREA Practitioners can look to cryolypolysis to sculpt the chins of patients with higher BMIs, based on a new U.S. Food and Drug Administration (FDA) clearance. In November, the FDA cleared Allergan's CoolSculpting to treat the submandibular area. The device is already cleared for submental fat. In addition, the FDA clearance was expanded to include patients with a BMI of up to 46.2 when treating the submental and submandibular areas. The effi cacy of the CoolSculpting treatment in the area right below the jawline was proved in a 22-week clinical study, which demonstrated an average 33 percent reduction in fat layer thickness after two treatments. Ad- ditionally, patient satisfaction with the treatment averaged 85 percent across three studies. "The CoolSculpting treatment is the clinically proven safe and effective leader in nonsurgical fat reduction with nine clearances and over 7 million treatments performed," said David Nicholson, chief research and development offi cer at Allergan. "This new indication to treat the submandibular area underscores Allergan's dedication to research and innovation within the body contouring category." A recent study published in JAMA Dermatology (November 7, 2018) found that platelet-rich plasma (PRP) injections are effective in improving the texture of aging skin. Murad Alam, MD, et al, per- formed a randomized clinical trial of 27 subjects (ages 18 to 70) with bilateral cheek rhytids of Glogau class II or greater. Each received 3mL intradermal injections of PRP to one cheek and sterile normal saline to the contralateral cheek. The participants did not know which side was injected with saline vs. PRP. At six months after a single treatment, masked participants noted that both fi ne and coarse texture improved more signifi - cantly with a single treatment of PRP than with normal saline. Both participants and raters found PRP to be nominally but not signifi - cantly superior to normal saline. PRP IMPROVES SKIN TEXTURE

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