NOV-DEC 2016

MedEsthetics—business education for medical practitioners—provides the latest noninvasive cosmetic procedures, treatment trends, product and equipment reviews, legal issues and medical aesthetics industry news.

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BEST PR ACTICES LEFT: POBA © GETTY IMAGES; RIGHT: MICHAELJUNG © GETTY IMAGES Two recent studies published in Occupational Medicine (London) revealed that work- place wellness programs and employee training in meditation and/or mindfulness help to reduce stress levels and improve performance among staff members. "Effects of an employee exercise programme on mental health" (published online August 23, 2016) followed 218 workers who took part in the Bruin Health Improve- ment Program (BHIP), a three-month exercise and nutrition wellness regimen. The researchers examined seven areas of health: physical and mental health, stress, en- ergy level, social satisfaction, self-effi cacy and quality of life. All participants showed signifi cant improvement across all seven domains, leading to less absenteeism and a more positive work attitude. In the August 2016 issue, J.M. Ravalier, et al, investigated the use of complementary therapies in the workplace by performing a literature review of Cochrane Central Register of Controlled Trials, PsycINFO, MEDLINE, AMED, CINAHL Plus, EMBASE and PubMed (January 2000-July 2015). They found that while evidence for relaxation interventions was inconclusive, mindfulness and meditation-based interventions were effective in improving workplace health and performance with the latter "demonstrat- ing some evidence of maintaining gains up to three months later." 10 NOVEMBER/DECEMBER 2016 | Med Esthetics Physicians may soon have a new tool available to help their rosacea patients. Foamix Pharma- ceuticals has released topline results of a Phase 2 clinical trial of its topical minocycline foam, FMX103, for the treatment of papulopustular rosacea. The double-blind, placebo-controlled trial included 233 subjects with moderate to se- vere rosacea enrolled at 18 sites. Subjects were randomized to receive either one of two doses of FMX103 (3% or 1.5%) or vehicle foam once daily over 12 weeks, followed by a 4-week post- treatment evaluation. Effi cacy endpoints were absolute change in the number of infl ammatory lesions and improvement in the Investigator Global Assessment (IGA) score of severity. The mean baseline lesion count for all groups ranged from 30.6 to 34.5; IGA scores were all moderate (3) or severe (4). At week 12, both doses of FMX103 signifi cantly reduced the number of lesions vs. vehicle with a mean reduction of 21.1 for the 1.5% dose, 19.9 for the 3% dose and 7.8 for vehicle; correspond- ing percent reductions were 61.4%, 55.5% and 29.7%. Both doses of FMX103 were signifi cantly better than vehicle in reducing the IGA score by 2 grades and in reaching a "clear" (score 0) or "almost clear" (1) rating at week 12. There were no serious treatment-related adverse events. TOPICAL MINOCYCLINE FOR ROSACEA ULTRASOUND INCREASES ACCURACY IN MASSETER INJECTIONS Encouraging Employee Wellness Improves Workplace Attitudes Individual anatomical variations can make it diffi cult to safely and effectively treat the masseter muscle with neuromodulators, leading researchers Natacha Quezada- Gaon, MD, et al, of Pontifi cal Catholic University's Department of Dermatology in Santiago, Chile, to investigate the use of ultrasound-guided injections. Thirty patients with bruxism were treated with botu linum toxin injections in each masseter muscle. The authors used ultrasound imaging and clinical markings—which were later com- pared—to guide their injections in 20 patients and clinical markings only in 10 cases. They found anatomical variants of the salivary glands in nearly 65% of subjects. In almost 40% of cases, the clinical markings for the anterior tip were incorrect and, based on ultrasound imaging, the marked injection sites fell outside of the muscle. In 20% of cases, ultrasound showed that the needle should be longer to enter the muscle. They concluded: "Ultrasound can be a potent tool for guiding the injection of botulinum toxin into the masseter muscles. It may contribute to a more personalized procedure, better cos metic results, and help to avoid potential complications." The study was published in the Journal of Cosmetic Dermatology (September 2016).

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